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Evidence-empowered Transfer Learning for Alzheimer's Disease

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posted on 2023-03-06, 17:16 authored by Tzuiunn OngTzuiunn Ong, Hana Kim, Kim, Jinseong Jang, Beomseok Sohn, Yoon Seong Choi, Dosik Hwang, Seong Jae Hwang, Jinyoung Yeo

Transfer learning has been widely utilized to mitigate the data scarcity problem in the field of Alzheimer’s disease (AD). Conventional transfer learning relies on re-using models trained on AD-irrelevant tasks such as natural image classification. However, it often leads to negative transfer due to the discrepancy between the non-medical source and medical target domains. To address this, we present evidence-empowered transfer learning for AD diagnosis. Unlike conventional approaches, we leverage an AD-relevant auxiliary task, namely morphological change prediction, without requiring additional MRI data, where the diagnosis model learns the evidential and transferable knowledge from morphological features in MRI scans. Experimental results demonstrate that our framework is not only effective in improving detection performance regardless of model capacity, but also more data-efficient, and faithful.


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Submitting Author's Institution

Yonsei University

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  • Korea, Republic of (South Korea)

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