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SARS-CoV-2 Detection using Colorimetric Plasmonic Sensors: A Proof-of-Concept Computational Study
preprint
posted on 2021-10-19, 09:04 authored by Somen BaidyaSomen Baidya, Ahmed M HassanAhmed M HassanTraditional molecular techniques for SARS-CoV-2
viral detection are time-consuming and can exhibit a high probability of false
negatives. In this work, we present a computational
study of SARS-CoV-2 detection using plasmonic gold nanoparticles. The
resonance wavelength of a SARS-CoV-2 virus was recently estimated to be in the
near-infrared region. By engineering gold nanospheres to specifically bind with
the outer surface of the SARS-CoV-2 virus, the resonance frequency can be
shifted to the visible range (380 nm – 700 nm). Moreover, we show that broadband
absorption will emerge in the visible spectrum when the virus is partially
covered with gold nanoparticles at a specific coverage percentage. This
broadband absorption can be used to guide the development of an efficient and
accurate colorimetric plasmon sensor for COVID-19 detection. Our observation
also suggests that this technique is unaffected by the number of protein spikes
present on the virus outer surface, hence can pave a potential path for a diagnostic
tool independent on the number of protein spikes.
Funding
N/A
History
Email Address of Submitting Author
sbg58@mail.umkc.eduORCID of Submitting Author
0000-0003-4102-1804Submitting Author's Institution
University of Missouri-Kansas CitySubmitting Author's Country
- United States of America