Targeted Sensitization of Glioblastoma Multiforme Using AAAPT Technology

Akay, Metin; Mendieta, Megan; Avci, Naze G.; Sanchez, Cristina Cereceda; Pandurangi, Raghu S.; Akay, Yasemin

doi:10.36227/techrxiv.24076533.v1

MM OJEMB_AMP_083123 Final.pdf (3.57 MB)

Targeted Sensitization of Glioblastoma Multiforme Using AAAPT Technology

preprint

posted on 2023-09-05, 15:40 authored by Metin AkayMetin Akay, Megan Mendieta, Naze G. Avci, Cristina Cereceda Sanchez, Raghu S. Pandurangi, Yasemin Akay

Microwell-generated GBM spheroids are sensitized by AAAPT drugs using targeted, cleavable linkages to reduce off-target toxicity.

Funding

THis study was supported by the University of Houston for the 3D drug screening studies, and genomic and proteomic analysis and by NIH-SBIR (R43CA214223,PI:RP) for the synthesis and characterization of AMPs.

History

Email Address of Submitting Author

makay58@gmail.com

ORCID of Submitting Author

0000-0002-2988-4669

Submitting Author's Institution

University of Houston

Submitting Author's Country

United States of America

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Keywords

Spheroids,GBM PEGDA AAAPT Technology micro environment

Licence

CC BY 4.0

Targeted Sensitization of Glioblastoma Multiforme Using AAAPT Technology

Funding

THis study was supported by the University of Houston for the 3D drug screening studies, and genomic and proteomic analysis and by NIH-SBIR (R43CA214223,PI:RP) for the synthesis and characterization of AMPs.

History

Email Address of Submitting Author

ORCID of Submitting Author

Submitting Author's Institution

Submitting Author's Country

Usage metrics

Categories

Keywords

Licence

Exports