Targeted Sensitization of Glioblastoma Multiforme Using AAAPT Technology
preprintposted on 2023-09-05, 15:40 authored by Metin AkayMetin Akay, Megan Mendieta, Naze G. Avci, Cristina Cereceda Sanchez, Raghu S. Pandurangi, Yasemin Akay
Microwell-generated GBM spheroids are sensitized by AAAPT drugs using targeted, cleavable linkages to reduce off-target toxicity.
THis study was supported by the University of Houston for the 3D drug screening studies, and genomic and proteomic analysis and by NIH-SBIR (R43CA214223,PI:RP) for the synthesis and characterization of AMPs.
Email Address of Submitting Authormakay58@gmail.com
ORCID of Submitting Author0000-0002-2988-4669
Submitting Author's InstitutionUniversity of Houston
Submitting Author's Country
- United States of America