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Imaging of Magnetic Nanoparticles with Permeability Tomography
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  • Alejandro Luis Veiga ,
  • Mariano Fernandez-Corazza ,
  • Marcela B. Fernández van Raap ,
  • Enrique M. Spinelli
Alejandro Luis Veiga
Universidad Nacional de La Plata

Corresponding Author:[email protected]

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Mariano Fernandez-Corazza
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Marcela B. Fernández van Raap
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Enrique M. Spinelli
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Abstract

Magnetic nanoparticles are being increasingly used in numerous biomedical applications for diagnosis and therapy. During the course of these applications nanoparticle biodegradation and body clearance may occur.
In this context, a portable, non-invasive, non-destructive and contactless imaging device can be relevant to trace the nanoparticle distribution before and after the medical procedure.
We present a method for $in\:vivo$ imaging the nanoparticles based on the magnetic induction technique, and we show how to properly tune it for magnetic permeability tomography, maximizing the permeability selectivity.
A tomograph prototype was designed and built to demonstrate the feasibility of the proposed method. It includes data collection, signal processing and image reconstruction.
Useful selectivity and resolution are achieved on phantoms and animals, proving that the device can be used to monitor the presence of magnetic nanoparticles without requiring any particular sample preparation. By this way, we show that magnetic permeability tomography may become a powerful technique to assist medical procedures.
Nov 2023Published in IEEE Transactions on Biomedical Engineering volume 70 issue 11 on pages 3216-3226. 10.1109/TBME.2023.3283787