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QRAGE – Simultaneous multiparametric quantitative MRI of water content, T1, T2*, and magnetic susceptibility at ultrahigh field strength
  • +7
  • Markus Zimmermann ,
  • Zaheer Abbas ,
  • Yannic Sommer ,
  • Alexander Lewin ,
  • Shukti Ramkiran ,
  • Jörg Felder,
  • Wieland Worthoff,
  • Ana-Maria Oros-Peusquens ,
  • Seong Dae Yun ,
  • N. Jon Shah
Markus Zimmermann
Forschungszentrum Jülich - Institute of Neuroscience and Medicine 4, Forschungszentrum Jülich - Institute of Neuroscience and Medicine 4

Corresponding Author:[email protected]

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Zaheer Abbas
Forschungszentrum Jülich - Institute of Neuroscience and Medicine 4
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Yannic Sommer
Forschungszentrum Jülich - Institute of Neuroscience and Medicine 4
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Alexander Lewin
Forschungszentrum Jülich - Institute of Neuroscience and Medicine 4
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Shukti Ramkiran
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Jörg Felder
Forschungszentrum Jülich - Institute of Neuroscience and Medicine 4
Wieland Worthoff
Forschungszentrum Jülich - Institute of Neuroscience and Medicine 4
Ana-Maria Oros-Peusquens
Forschungszentrum Jülich - Institute of Neuroscience and Medicine 4
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Seong Dae Yun
Forschungszentrum Jülich - Institute of Neuroscience and Medicine 4
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N. Jon Shah
Forschungszentrum Jülich - Institute of Neuroscience and Medicine 4
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Abstract

QRAGE is a novel imaging sequence and reconstruction method for the simultaneous mapping of multiple quantitative MRI parameters, including water content, T1, T2*, and magnetic susceptibility at ultrahigh field strength. QRAGE employs a novel ME-MPnRAGE sequence that acquires 171 contrast images at different inversion and echo time points, enabling accurate and precise parameter estimation. It further incorporates a novel model-based reconstruction method, MIRAGE2, that leverages prior knowledge of temporal signal evolution represented as damped complex exponentials by minimizing local Block-Hankel and Casorati matrices. Parameter maps are derived from the reconstructed contrast images through postprocessing steps.
11 Jan 2024Submitted to TechRxiv
22 Jan 2024Published in TechRxiv