There has been much discussion about the impact and future of artificial intelligence (AI) in our lives and future generations. Many experts even believe that AI will “rule” the world. Artificial Neural Networks (ANN) have provided a convenient and often extremely accurate solution to problems within all fields, and can be seen as advanced general-purpose regression models that try to mimic the behavior of the human brain. The adoption and use of ANN-based methods in the Mechanistic-Empirical Pavement Design Guide is a clear sign of the successful use of neural nets in geomechanical and pavement systems. This work aims to provide an extensive and detailed state-of-the-art of the application of ANN models to pavement management, materials and design problems. Unlike former review articles published before 2014, this work is more descriptive and makes the review much more appealing to the reader by highlighting numerically and/or graphically the effectiveness and possible drawbacks of each ANN application.