The successful realization of the climate goals agreed upon in the European Union’s COP21 commitments makes a fundamental change of the European energy system necessary. In particular, for a reduction of greenhouse gas emissions over 80%, the use of renewable energies must be increased not only in the electricity sector but also across all energy sectors, such as heat and mobility. Furthermore, a progressive integration of renewable energies increases the risk of congestions in the transmission grid and makes network expansion necessary. An efficient planning for future energy systems must comprise the coupling of energy sectors as well as interdependencies of generation and transmission grid infrastructure. However, in traditional energy system planning, these aspects are considered as decoupled. Therefore, the project PlaMES develops an approach for integrated planning of multi-energy systems on a European scale. This paper aims at analyzing the model requirements and describing the modeling approach.