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A Novel Pumping Principle for a Total Artificial Heart
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  • Tim Bierewirtz ,
  • Krishnaraj Narayanaswamy ,
  • Rosario Giuffrida ,
  • Tim Rese ,
  • Dominik Bortis ,
  • Daniel Zimpfer ,
  • Johann Walter Kolar ,
  • Ulrich Kertzscher ,
  • Marcus Granegger
Tim Bierewirtz
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Krishnaraj Narayanaswamy
Medical University of Vienna

Corresponding Author:[email protected]

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Rosario Giuffrida
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Dominik Bortis
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Daniel Zimpfer
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Johann Walter Kolar
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Ulrich Kertzscher
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Marcus Granegger
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Objective: Total artificial hearts (TAH) are used as a temporary treatment for severe biventricular heart failure. Long-term cardiac replacement is hampered by limited durability and complication rates, which may be attributable to the modus operandi of state-of-the-art pumping systems. The aim of this study was to assess the feasibility of a novel valveless pumping principle for a durable pulsatile TAH (ShuttlePump).
Methods: With a rotating and linearly shuttling piston within a cylindrical housing with 2 in- and outlets, the pump features only one single moving part and delivers pulsatile flow to both systemic and pulmonary circulation. The pump and actuation system were designed iteratively based on analytical and in silico methods, utilizing finite element methods (FEM) and computational fluid dynamics (CFD) Pump characteristics were evaluated experimentally in a mock circulation loop mimicking the cardiovascular system, while hemocompatibility related parameters were calculated numerically.
Results: Pump characteristics cover the entire required operating range for a TAH (2.5 - 9L/min at 50 - 160mmHg arterial pressures) at stroke frequencies of 1.5 - 5Hz while balancing left and right atrial pressures. FEM analysis showed a mean overall copper losses of 8.84W, resulting in local blood temperature rise of < 2k. The CFD results of normalized index of hemolysis was 3.57 mg/100L and 95% of the pumps blood volume was exchanged after 1.42s.
Conclusion: This study indicates feasibility of a novel pumping system for a TAH with numerical and experimental results substantiating further development of the ShuttlePump.
2023Published in IEEE Transactions on Biomedical Engineering on pages 1-10. 10.1109/TBME.2023.3306888